产品名称

SirReal 2

产品货号

Axon 2453 CAS [709002-46-0] MF C22H20N4OS2MW 420.55 Purity: 98% Soluble in DMSO Description SIRT2 inhibitor (IC50 value 0.14 µM) with in vivo activity, showing >1000 fold selectivity over other Class-I sirtuins SIRT1 and SIRT3. Application of SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. KEYWORDS: SIRT2 inhibitor | Axon 2453 | SirReal2 | 709002-46-0 | Histone | SIRT | Inhibitor | Sirtuin | tubulin | checkpoint protein | BubR1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SirReal 2

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2453

CAS [709002-46-0]

MF C22H20N4OS2
MW 420.55

Purity: 98%
Soluble in DMSO

SirReal 2

Description

SIRT2 inhibitor (IC50 value 0.14 µM) with in vivo activity, showing >1000 fold selectivity over other Class-I sirtuins SIRT1 and SIRT3. Application of SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1.

T. Rumpf et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT

SIRT2 inhibitor with >1000 fold selectivity over SIRT1 and SIRT3

Chemical name

2-(4,6-dimethylpyrimidin-2-ylthio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide

Parent CAS No.

[709002-46-0]

产品资料