产品名称

AK 7

产品货号

Axon 2270 CAS [420831-40-9] MF C19H21BrN2O3SMW 437.35 Purity: 100% Soluble in DMSO Description Potent, brain-permeable and selective inhibitor of SIRT2 (IC50 values >50 μM, 15.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Treatment with AK 7 showed a SIRT2-dependent nucleo-cytoplasmic trafficking in primary striatal neurons of the master regulator of cholesterol biosynthesis, SREBP-2, and resulted in protection of neurons in an in vitro model of Huntington's disease (HD). AK 7 is slightly less potent in vitro than its analogue AK 1 (Axon 2269). References Certificates Categories Extra info T.F. Outeiro et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007, 317, 516-519. R. Luthi-Carter et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. USA. 2010, 107, 7927-7932. D.M. Taylor et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem. Biol. 2011, 6, 540-546. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT Potent, brain-permeable and selective inhibitor of SIRT2 Chemical name 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide Parent CAS No. [420831-40-9] Order Size Unit Price Stock 10 mg €90.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AK 7

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2270

CAS [420831-40-9]

MF C19H21BrN2O3S
MW 437.35

Purity: 100%
Soluble in DMSO

AK 7

Description

Potent, brain-permeable and selective inhibitor of SIRT2 (IC50 values >50 μM, 15.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Treatment with AK 7 showed a SIRT2-dependent nucleo-cytoplasmic trafficking in primary striatal neurons of the master regulator of cholesterol biosynthesis, SREBP-2, and resulted in protection of neurons in an in vitro model of Huntington's disease (HD).
AK 7 is slightly less potent in vitro than its analogue AK 1 (Axon 2269).

T.F. Outeiro et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007, 317, 516-519.

R. Luthi-Carter et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. USA. 2010, 107, 7927-7932.

D.M. Taylor et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem. Biol. 2011, 6, 540-546.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT

Potent, brain-permeable and selective inhibitor of SIRT2

Chemical name

3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide

Parent CAS No.

[420831-40-9]

产品资料