产品名称

AK 1

产品货号

Axon 2269 CAS [330461-64-8] MF C19H21N3O5SMW 403.45 Purity: 100% Soluble in DMSO Description Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 (IC50 values >50 μM, 12.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Short-term treatment with AK 1 produced large statistically significant changes in RNA expression in untransduced, Htt171-18Q- and Htt171-82Q-expressing neurons and confirm the hypothesis that AK 1-mediated neuroprotection is correlated with the negative regulation of sterol biosynthesis.AK 1 is among the first brain-permeable SIRT2 inhibitors that mediate neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington’s disease model. More potent in vitro than its analogue AK 7 (Axon 2270). References Certificates Categories Extra info T.F. Outeiro et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007, 317, 516-519. R. Luthi-Carter et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. USA. 2010, 107, 7927-7932. D.M. Taylor et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem. Biol. 2011, 6, 540-546. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 Chemical name 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide Parent CAS No. [330461-64-8] Order Size Unit Price Stock 10 mg €90.00 In Stock

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现货询价，电话：010-67529703

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axonmedchem

产品概述

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AK 1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2269

CAS [330461-64-8]

MF C19H21N3O5S
MW 403.45

Purity: 100%
Soluble in DMSO

AK 1

Description

Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 (IC50 values >50 μM, 12.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Short-term treatment with AK 1 produced large statistically significant changes in RNA expression in untransduced, Htt171-18Q- and Htt171-82Q-expressing neurons and confirm the hypothesis that AK 1-mediated neuroprotection is correlated with the negative regulation of sterol biosynthesis.
AK 1 is among the first brain-permeable SIRT2 inhibitors that mediate neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington’s disease model. More potent in vitro than its analogue AK 7 (Axon 2270).

T.F. Outeiro et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007, 317, 516-519.

R. Luthi-Carter et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. USA. 2010, 107, 7927-7932.

D.M. Taylor et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem. Biol. 2011, 6, 540-546.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT

Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3

Chemical name

3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide

Parent CAS No.

[330461-64-8]

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