| 产品名称 | MG 132 |
| 产品货号 | Axon 1869 CAS [133407-82-6] MF C26H41N3O5MW 475.62 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). MG132 inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG132 also activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. References Certificates Categories Extra info D Banerjee and A Liefshitz. Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 2001, 21(6A), 3941-3947. VJ Palombella et al. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994, 78(5), 773-785. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology MAPK (JNK) Proteasome 26S NF-κB Ubiquitin EC 3.4 Inhibitor of 26S proteasome Chemical name benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate Parent CAS No. [133407-82-6] Order Size Unit Price Stock 10 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
MG 132Axon 1869 CAS [133407-82-6] MF C26H41N3O5
Description
Specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). MG132 inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG132 also activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis.
Inhibitor of 26S proteasome
Chemical namebenzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate Parent CAS No.[133407-82-6] |
| 产品资料 |
