产品名称

NSC 687852 - b-AP15

产品货号

Axon 2228 CAS [1009817-63-3] MF C22H17N3O6MW 419.39 Purity: 98% Soluble in DMSO Description Inhibitor of two 19S regulatory-particle–associated deubiquitinases (DUBs), ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) showing tumor growth inhibition in vivo. NSC 687852 shows IC50 values of 0.5 μM and 2.1 μM in cathepsin-dependent caspase-cleavage and in purified 19S proteasome Ub-AMC cleavage assays respectively.NSC 687852 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2. UNC 687852 does not inhibit the non proteasomeal DUBs UCHL-1/3, USP-2/7/8 and BAP1. References Certificates Categories Extra info P. D'Arcy et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat. Med. 2011, 17, 1636-1640. M. Berndtsson et al. Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int. J. Cancer. 2009, 124, 1463-1469. H.N. Pati et al. Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells. Eur. J. Med. Chem. 2008, 43, 1-7. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Ubiquitin EC 3.4.19.12 Deubiquitinase Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) Chemical name (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one Parent CAS No. [1009817-63-3] Order Size Unit Price Stock 10 mg €90.00 In Stock

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axonmedchem

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NSC 687852 - b-AP15

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2228

CAS [1009817-63-3]

MF C22H17N3O6
MW 419.39

Purity: 98%
Soluble in DMSO

NSC 687852

Description

Inhibitor of two 19S regulatory-particle–associated deubiquitinases (DUBs), ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) showing tumor growth inhibition in vivo. NSC 687852 shows IC50 values of 0.5 μM and 2.1 μM in cathepsin-dependent caspase-cleavage and in purified 19S proteasome Ub-AMC cleavage assays respectively.NSC 687852 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2. UNC 687852 does not inhibit the non proteasomeal DUBs UCHL-1/3, USP-2/7/8 and BAP1.