| 产品名称 | P 005091 - P 5091 |
| 产品货号 | Axon 2011 CAS [882257-11-6] MF C12H7Cl2NO3S2MW 348.22 Purity: 99% Soluble in DMSO Description Selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) and the closely related USP47; inhibits USP7-mediated p53 deubiquitination; enhances the degradation of the USP7 substrate HDM2 in tumor cells; induces apoptosis in MM cells resistant to conventional and bortezomib (Axon 1810) therapies References Certificates Categories Extra info B Nicholson, KGS Kumar. The multifaceted roles of USP7: new therapeutic opportunities. Cell Biochem. Biophys. 2011, 60(1-2), 61-68. D Chauhan et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 2012, 22(3), 345-358. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Ubiquitin EC 3.4.19.12 Deubiquitinase Inhibitor of deubiquitinase USP7 and USP47 Chemical name 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone Parent CAS No. [882257-11-6] Order Size Unit Price Stock 10 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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P 005091 - P 5091Axon 2011 CAS [882257-11-6] MF C12H7Cl2NO3S2
DescriptionSelective and potent inhibitor of ubiquitin-specific protease 7 (USP7) and the closely related USP47; inhibits USP7-mediated p53 deubiquitination; enhances the degradation of the USP7 substrate HDM2 in tumor cells; induces apoptosis in MM cells resistant to conventional and bortezomib (Axon 1810) therapies
Inhibitor of deubiquitinase USP7 and USP47
Chemical name1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone Parent CAS No.[882257-11-6] |
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