产品名称

GSK 461364

产品货号

Axon 1688 CAS [929095-18-1] MF C27H28F3N5O2SMW 543.60 Purity: 99% Optical purity: 99% ee Soluble in DMSO Description Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (Ki: 2.2 nM) over PLK2 and PLK3. References Certificates Categories Extra info TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92. KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.11.21 PLK PLK1 inhibitor Chemical name (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide Parent CAS No. [929095-18-1] Order Size Unit Price Stock 5 mg €105.00 In Stock

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现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GSK 461364

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1688

CAS [929095-18-1]

MF C27H28F3N5O2S
MW 543.60

Purity: 99%
Optical purity: 99% ee
Soluble in DMSO

GSK 461364

Description

Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (Ki: 2.2 nM) over PLK2 and PLK3.

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

PLK1 inhibitor

Chemical name

(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Parent CAS No.

[929095-18-1]

产品资料