产品名称

GSK 461364 analogue II

产品货号

Axon 1626 CAS [929095-22-7] MF C27H27F3N4O3SMW 544.59 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent Polo-like kinase (PLK) inhibitor, selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 270 nM) References Certificates Categories Extra info TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92. KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation EC 2.7.11.21 PLK PLK1 Inhibitor Chemical name (R)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide Parent CAS No. [929095-22-7] Order Size Unit Price Stock 5 mg €110.00 In Stock

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现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GSK 461364 analogue II

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1626

CAS [929095-22-7]

MF C27H27F3N4O3S
MW 544.59

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

GSK 461364 analogue II

Description

Potent Polo-like kinase (PLK) inhibitor, selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 270 nM)

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

PLK1 Inhibitor

Chemical name

(R)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Parent CAS No.

[929095-22-7]

产品资料