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产品名称 Aurora A inhibitor I
产品货号 Axon 1597 CAS [1158838-45-9] MF C31H31ClFN7O2MW 588.07 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases. This ligand has much higher selectivity of Aurora A vs Aurora B than another recently described relatively selective Aurora A inhibitor MLN8054, which shows 43-fold selectivity for Aurora A over Aurora B in enzymatic assays References Certificates Categories Extra info I Aliagas-Martin et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J. Med. Chem. 2009, 52(10), 3300-7. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora A inhibitor Chemical name N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide Parent CAS No. [1158838-45-9] Order Size Unit Price Stock 5 mg €125.00 In Stock
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产品品牌 axonmedchem
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Aurora A inhibitor I

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1597

CAS [1158838-45-9]

MF C31H31ClFN7O2
MW 588.07

  • Purity: 99%
  • Soluble in DMSO

Aurora A inhibitor I

Description

Potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.
This ligand has much higher selectivity of Aurora A vs Aurora B than another recently described relatively selective Aurora A inhibitor MLN8054, which shows 43-fold selectivity for Aurora A over Aurora B in enzymatic assays
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