产品名称

BAY 58-2667 hydrochloride - Cinaciguat hydrochloride

产品货号

Axon 2172 CAS [646995-35-9] MF C36H39NO5.HClMW 602.16 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator with haemodynamic effect similar to that of nitroglycerin (Ki value 6-8 nM in competition binding studies). Acts specifically on oxidized/haem-free sGC by binding to the enzyme's haem pocket and mimicking the nitric-oxide-bound haem group. BAY 58-2667 is in clinical development for the treatment of acute decompensated heart failure (ADHF). KEYWORDS: BAY 58-2667 hydrochloride | supplier | sGC activator | Cinaciguat hydrochloride | BAY58-2667 | CAS [646995-35-9] | [329773-35-5] | GTP | sGC | soluble | guanylyl cyclase | NO | nitric oxide | heart failure | cardiac | ADHF

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BAY 58-2667 hydrochloride - Cinaciguat hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2172

CAS [646995-35-9]

MF C36H39NO5.HCl
MW 602.16

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

BAY 58-2667 hydrochloride

Description

Potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator with haemodynamic effect similar to that of nitroglycerin (Ki value 6-8 nM in competition binding studies). Acts specifically on oxidized/haem-free sGC by binding to the enzyme's haem pocket and mimicking the nitric-oxide-bound haem group. BAY 58-2667 is in clinical development for the treatment of acute decompensated heart failure (ADHF).