产品名称

CK 1827452 - Omecamtiv Mecarbil | CK-452

产品货号

Axon 1835 CAS [873697-71-3] MF C20H24FN5O3MW 401.43 Purity: 99% Soluble in DMSO Description Selective cardiac specific myosin activator; clinically tested for its role in the treatment of left ventricular systolic heart failure. KEYWORS: Omecamtiv Mecarbil | supplier | Myosin activator | CK 1827452 | CK-452 | CK1827452 | CAS [873697-71-3] | ATP | ATPase (cardiac specific myosin) | Activator | left ventricular systolic | heart failure | LVSHF

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CK 1827452 - Omecamtiv Mecarbil | CK-452

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1835

CAS [873697-71-3]

MF C20H24FN5O3
MW 401.43

Purity: 99%
Soluble in DMSO

CK 1827452

Description

Selective cardiac specific myosin activator; clinically tested for its role in the treatment of left ventricular systolic heart failure.

KEYWORS: Omecamtiv Mecarbil | supplier | Myosin activator | CK 1827452 | CK-452 | CK1827452 | CAS [873697-71-3] | ATP | ATPase (cardiac specific myosin) | Activator | left ventricular systolic | heart failure | LVSHF

F Malik et al. The Selective Cardiac Myosin Activator, CK-1827452, a Calcium-Independent Inotrope, Increases Left Ventricular Systolic Function by Increasing Ejection Time Rather than the Velocity of Contraction. Circulation 2006, 114, 441.

JR Teerlink. A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail Rev. 2009, 14(4), 289–298.

RJ Solaro. CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. IDrugs. 2009 Apr;12(4):243-51.

Cardiovascular Cell Signaling & Oncology EC 3.6.4.1 ATPase (myosin)

Cardiac specific myosin ATPase activator

Chemical name

methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

Parent CAS No.

[873697-71-3]

产品资料