| 产品名称 | MYK-461 - Mavacamten | SAR439152 |
| 产品货号 | Axon 2683 CAS [1642288-47-8] MF C15H19N3O2MW 273.33 Purity: 100% Optical purity: Optically pure Soluble in 0.1 N NaOH(aq) and DMSO Description MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM. KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
MYK-461 - Mavacamten | SAR439152Axon 2683 CAS [1642288-47-8] MF C15H19N3O2
DescriptionMYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM. KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin
Cardiac specific myosin ATPase inhibitor
Chemical name(S)-3-Isopropyl-6-(1-phenylethylamino)pyrimidine-2,4(1H,3H)-dione Parent CAS No.[1642288-47-8] |
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