| 产品名称 | SCH 529074 |
| 产品货号 | Axon 2244 CAS [922150-11-6] MF C31H36Cl2N6MW 563.56 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Small molecule activator of mutant p53 which binds p53 DNA binding domain (DBD; Kd value 1-2 μM). SCH 529074 restores growth-suppressive function to mutant p53 (R273H and the structural mutant R249S) by acting as a chaperone and interrupts HDM2-mediated ubiquitination of wild type p53. References Certificates Categories Extra info M. Demma et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination (...). J. Biol. Chem. 2010, 285, 10198-10212. F. Essmann et al. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br. J. Pharmacol. 2012, 165, 328-344. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1 Small molecule activator of mutant p53. Chemical name N1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine Parent CAS No. [922150-11-6] Order Size Unit Price Stock 5 mg €100.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
SCH 529074Axon 2244 CAS [922150-11-6] MF C31H36Cl2N6
Description
Small molecule activator of mutant p53 which binds p53 DNA binding domain (DBD; Kd value 1-2 μM). SCH 529074 restores growth-suppressive function to mutant p53 (R273H and the structural mutant R249S) by acting as a chaperone and interrupts HDM2-mediated ubiquitination of wild type p53.
Small molecule activator of mutant p53.
Chemical nameN1-(2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine Parent CAS No.[922150-11-6] |
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