产品名称

Pifithrin-α hydrobromide - PFT-α

产品货号

Axon 1871 CAS [63208-82-2] MF C16H18N2OS.HBrMW 367.30 Purity: 99% Soluble in DMSO Description Pifithrin-α is an inhibitor of p53 protein; reversibly blocks p53-dependent transcriptional activation and apoptosis; protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53 References Certificates Categories Extra info PG Komarov et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 1999, 285(5434), 1733-7. PJM Murphy et al. Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation. J. Biol. Chem. 2004, 279, 30195-30201. D Sohn et al. Pifithrin-α protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death and Differentiation. 2009, 16, 869–878. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1 Stem Cell Differentiator Inhibitor of p53 protein Chemical name 2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-p-tolylethanone hydrobromide Parent CAS No. [206983-57-5] Order Size Unit Price Stock 10 mg €95.00 In Stock

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axonmedchem

产品概述

产品详情

Pifithrin-α hydrobromide - PFT-α

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1871

CAS [63208-82-2]

MF C16H18N2OS.HBr
MW 367.30

Purity: 99%
Soluble in DMSO

Pifithrin-α hydrobromide

Description

Pifithrin-α is an inhibitor of p53 protein; reversibly blocks p53-dependent transcriptional activation and apoptosis; protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53

PG Komarov et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 1999, 285(5434), 1733-7.

PJM Murphy et al. Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation. J. Biol. Chem. 2004, 279, 30195-30201.

D Sohn et al. Pifithrin-α protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death and Differentiation. 2009, 16, 869–878.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1 Stem Cell Differentiator

Inhibitor of p53 protein

Chemical name

2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-p-tolylethanone hydrobromide

Parent CAS No.

[206983-57-5]

产品资料