产品名称

JNJ 26854165 - Serdemetan

产品货号

Axon 1538 CAS [881202-45-5] MF C21H20N4MW 328.41 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Oral HDM2 inhibitor (or antagonist), which showed potent activity against multiple myeloma (MM) cells in vitro and ex vivo; potential agent to restore p53 function and to potentially impact other HDM2 dependent pathways. Note: Its directly water soluble form, JNJ 26854165 dihydrochloride (Axon 1586), is also available. KEYWORDS: JNJ26854165 | Supplier | HDM2 inhibitor | Serdemetan | JNJ26854165 | CAS [881202-45-5] | [881202-79-5] | p53 | HDM-MDM| Inhibitor | antagonist | multiple myeloma | MM | pathways

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JNJ 26854165 - Serdemetan

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1538

CAS [881202-45-5]

MF C21H20N4
MW 328.41

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

JNJ 26854165

Description

Oral HDM2 inhibitor (or antagonist), which showed potent activity against multiple myeloma (MM) cells in vitro and ex vivo; potential agent to restore p53 function and to potentially impact other HDM2 dependent pathways.

Note: Its directly water soluble form, JNJ 26854165 dihydrochloride (Axon 1586), is also available.

T. Stühmer et al. A first-in-class HDM2-inhibitor (JNJ-26854165) in phase I development shows potent activity against multiple myeloma (MM) cells in vitro and ex vivo. J Clin Oncol 26: 2008, 26, 15S.

K Kojima et al. The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias. Mol. Cancer Ther. 2010, 9(9), 2545–2557.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM

HDM2 inhibitor

Chemical name

N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine

Parent CAS No.

[881202-45-5]

产品资料