| 产品名称 | SP 141 |
| 产品货号 | Axon 2437 CAS [1253491-42-7] MF C15H11N3OMW 249.27 Purity: 99% Soluble in DMSO Description Specific MDM2 inhibitor (Ki value 28 nM in a FP-based MDM2 binding assay) with potent therapeutic effects in breast cancer models, regardless of p53 status. SP141 directly binds to MDM2, inhibits MDM2 expression and induces its autoubiquitination and proteasomal degradation. References Certificates Categories Extra info W. Wang et al. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat Commun. 2014 Oct 1;5:5086. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression DNA-damage Response Ubiquitin EC 6.3.2.19 HDM-MDM Specific MDM2 inhibitor with therapeutic effects in breast cancer models Chemical name 6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole Parent CAS No. [1253491-42-7] Order Size Unit Price Stock 10 mg €120.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
SP 141Axon 2437 CAS [1253491-42-7] MF C15H11N3O
Description
Specific MDM2 inhibitor (Ki value 28 nM in a FP-based MDM2 binding assay) with potent therapeutic effects in breast cancer models, regardless of p53 status. SP141 directly binds to MDM2, inhibits MDM2 expression and induces its autoubiquitination and proteasomal degradation.
Specific MDM2 inhibitor with therapeutic effects in breast cancer models
Chemical name6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole Parent CAS No.[1253491-42-7] |
| 产品资料 |
