| 产品名称 | SMURF1 inhibitor A01 - A01 |
| 产品货号 | Axon 2426 CAS [1007647-73-5] MF C22H20ClF3N4O3SMW 512.93 Purity: 99% Soluble in DMSO Description SMAD ubiquitination regulatory factor-1 (SMURF1) E3 ubiquitin-protein ligase inhibitor (Kd value 3.7 nM), that strongly inhibits Smad1/5 ubiquitination under rhBMP-2 stimulation. A01 enhances BMP signaling responsiveness in C2C12 cells, and potentiates BMP-2 induced osteoblastic activity. References Certificates Categories Extra info Y. Cao et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Wnt-β-Catenin MAPK Ubiquitin EC 6.3.2.19 Ubiquitin Ligase (E3; SMURF) Inhibitor of E3 ubiquitin-protein ligase SMURF1 Chemical name (4-(4-chloro-3-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone Parent CAS No. [1007647-73-5] Order Size Unit Price Stock 10 mg €115.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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SMURF1 inhibitor A01 - A01Axon 2426 CAS [1007647-73-5] MF C22H20ClF3N4O3S
Description
SMAD ubiquitination regulatory factor-1 (SMURF1) E3 ubiquitin-protein ligase inhibitor (Kd value 3.7 nM), that strongly inhibits Smad1/5 ubiquitination under rhBMP-2 stimulation. A01 enhances BMP signaling responsiveness in C2C12 cells, and potentiates BMP-2 induced osteoblastic activity.
Inhibitor of E3 ubiquitin-protein ligase SMURF1
Chemical name(4-(4-chloro-3-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone Parent CAS No.[1007647-73-5] |
| 产品资料 |
