产品名称

SJ 172550

产品货号

Axon 2164 CAS [431979-47-4] MF C22H21ClN2O5MW 428.87 Purity: 99% Soluble in DMSO Description First small molecule inhibitor of MDMX with 10-fold selectivity over closely related MDM2 (EC50 2.3 μM vs 26.0 μM) which effectively kills MDMX-amplified retinoblastoma cells. SJ 172550 reversibly binds the p53-binding pocket of MDM, disrupts the MDMX-p53 interaction, and thereby frees p53 to induce apoptosis. The effect of SJ 172550 is additive when combined with an MDM2 inhibitor Nutlin 3a (Axon 1880). It may be useful for treating tumors that express wild-type p53 References Certificates Categories Extra info D Reed et al. Identification and characterization of the first small molecule inhibitor of MDMX. J. Biol. Chem. 2010, 285, 10786-10796. JC Badciong et al. MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J. Biol. Chem. 2002, 277, 49668-49675. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression EC 6.3.2.19 HDM-MDM Small molecule inhibitor of MDMX Chemical name (E/Z)-methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate Parent CAS No. [431979-47-4] Order Size Unit Price Stock 5 mg €95.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SJ 172550

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2164

CAS [431979-47-4]

MF C22H21ClN2O5
MW 428.87

Purity: 99%
Soluble in DMSO

SJ 172550

Description

First small molecule inhibitor of MDMX with 10-fold selectivity over closely related MDM2 (EC50 2.3 μM vs 26.0 μM) which effectively kills MDMX-amplified retinoblastoma cells.
SJ 172550 reversibly binds the p53-binding pocket of MDM, disrupts the MDMX-p53 interaction, and thereby frees p53 to induce apoptosis. The effect of SJ 172550 is additive when combined with an MDM2 inhibitor Nutlin 3a (Axon 1880). It may be useful for treating tumors that express wild-type p53

D Reed et al. Identification and characterization of the first small molecule inhibitor of MDMX. J. Biol. Chem. 2010, 285, 10786-10796.

JC Badciong et al. MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J. Biol. Chem. 2002, 277, 49668-49675.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression EC 6.3.2.19 HDM-MDM

Small molecule inhibitor of MDMX

Chemical name

(E/Z)-methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate

Parent CAS No.

[431979-47-4]

产品资料