产品名称

Nutlin-3b - Nutlin-3, (+)-

产品货号

Axon 1881 CAS [675576-97-3] MF C30H30Cl2N4O4MW 581.49 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Nutlin-3b is a 150-fold less potent (+)-enantiomer of Nutlin-3 (Axon 1585) as p53 MDM2 antagonist or inhibitor, in comparison with more potent opposite (-)-enantiomer Nutlin-3a (Axon 1880); useful as a negative control for non-Mdm2 related cellular activities. KEYWORDS: Nutlin-3b | MDM2 inhibitor | Nutlin-3, (+)- | Nutlin3b | Nutlin3 | Nutlin 3b | Nutlin 3 | CAS [675576-97-3] | p53 | HDM-MDM | Inhibitor | Enzymes

产品价格

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

Nutlin-3b - Nutlin-3, (+)-

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1881

CAS [675576-97-3]

MF C30H30Cl2N4O4
MW 581.49

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Nutlin-3b

Description

Nutlin-3b is a 150-fold less potent (+)-enantiomer of Nutlin-3 (Axon 1585) as p53 MDM2 antagonist or inhibitor, in comparison with more potent opposite (-)-enantiomer Nutlin-3a (Axon 1880); useful as a negative control for non-Mdm2 related cellular activities.

KEYWORDS: Nutlin-3b | MDM2 inhibitor | Nutlin-3, (+)- | Nutlin3b | Nutlin3 | Nutlin 3b | Nutlin 3 | CAS [675576-97-3] | p53 | HDM-MDM | Inhibitor | Enzymes

V Manfé et al. MDM2 Inhibitor Nutlin-3a Induces Apoptosis and Senescence in Cutaneous T-Cell Lymphoma: Role of p53. J. Invest. Dermatol. 2012, 132, 1487-1496.

E Drakos et al. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia 2011, 25, 856–867.

F Zhang et al. MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport. Biochem. Pharmacol. 2011, 82(1), 24-34.

H Hasegawa et al. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells. Leukemia 2009, 23, 2090–2101.

TA Davis and JN Johnston. Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (-)-Nutlin-3, a potent p53/MDM2 inhibitor. Chem. Sci. 2011, 2, 1076-1079.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM

Less potent (+)-enantiomer of Nutlin-3

Chemical name

4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Parent CAS No.

[675576-97-3]

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