产品名称

Nutlin-3a - Nutlin-3, (-)-

产品货号

Axon 1880 CAS [675576-98-4] MF C30H30Cl2N4O4MW 581.49 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Nutlin-3a is an antagonist or inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. *Note: Nutlin-3a (Axon 1880) is the 150-fold more potent (-)-enantiomer of Nutlin-3 (Axon 1585), in comparision with the opposite (+)-enantiomer Nutlin-3b (Axon 1881). Presently, much attention has been given to Nutlin-3a and its absolute stereo-assignment is now known. References Certificates Categories Extra info V Manfé et al. MDM2 Inhibitor Nutlin-3a Induces Apoptosis and Senescence in Cutaneous T-Cell Lymphoma: Role of p53. J. Invest. Dermatol. 2012, 132, 1487-1496. E Drakos et al. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia 2011, 25, 856–867. F Zhang et al. MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport. Biochem. Pharmacol. 2011, 82(1), 24-34. H Hasegawa et al. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells. Leukemia 2009, 23, 2090–2101. TA Davis and JN Johnston. Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (-)-Nutlin-3, a potent p53/MDM2 inhibitor. Chem. Sci. 2011, 2, 1076-1079. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM Inhibitor of MDM2 Chemical name 4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one Parent CAS No. [675576-98-4] Order Size Unit Price Stock 2 mg €95.00 In Stock

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axonmedchem

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Nutlin-3a - Nutlin-3, (-)-

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1880

CAS [675576-98-4]

MF C30H30Cl2N4O4
MW 581.49

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Nutlin-3a

Description

Nutlin-3a is an antagonist or inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53.

*Note: Nutlin-3a (Axon 1880) is the 150-fold more potent (-)-enantiomer of Nutlin-3 (Axon 1585), in comparision with the opposite (+)-enantiomer Nutlin-3b (Axon 1881). Presently, much attention has been given to Nutlin-3a and its absolute stereo-assignment is now known.