| 产品名称 | HLI 373 |
| 产品货号 | Axon 1643 CAS [N.A.] MF C18H23N5O2.2HClMW 414.33 Purity: 98% Soluble in water and DMSO Description A water soluble and potent Hdm2 inhibitor that inhibits the ubiquitin ligase activity of Hdm2, stabilizes p53 and activates p53-dependent transcription, and induces cell death; HLI 373 is effective in inducing apoptosis of several tumor cells lines that are sensitive to DNA-damaging agents References Certificates Categories Extra info J Kitagaki et al. Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol. Cancer Ther. 2008, 7(8), 2445–2454. Y Yang et al. Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009, 100(1), 24-28. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM HDM2 inhibitor Chemical name 5-(3-(dimethylamino)propylamino)-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione hydrochloride Parent CAS No. [502137-98-6] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
HLI 373Axon 1643 CAS [N.A.] MF C18H23N5O2.2HCl
Description
A water soluble and potent Hdm2 inhibitor that inhibits the ubiquitin ligase activity of Hdm2, stabilizes p53 and activates p53-dependent transcription, and induces cell death; HLI 373 is effective in inducing apoptosis of several tumor cells lines that are sensitive to DNA-damaging agents
HDM2 inhibitor
Chemical name5-(3-(dimethylamino)propylamino)-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione hydrochloride Parent CAS No.[502137-98-6] |
| 产品资料 |
