| 产品名称 | Nutlin-3 |
| 产品货号 | Axon 1585 CAS [548472-68-0] MF C30H30Cl2N4O4MW 581.49 Purity: 99% Soluble in DMSO and Ethanol Description MDM2 antagonist, which binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice. Note: Its two enantiomers, more active (-)-enantiomer Nutlin-3a (Axon 1880) and less active (+)-enantiomer Nutlin-3b (Axon 1881), are also available. References Certificates Categories Extra info LT Vassilev et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2. Science 2004, 303, 844-848. S Shangary and S Wang. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Ann. Rev. Pharmacol. Toxicol. 2008, 49: 223–241. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Transcription Factors p53-Tumor Suppression Ubiquitin EC 6.3.2.19 HDM-MDM MDM2 inhibitor (p53 specific) Chemical name 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one Parent CAS No. [548472-68-0] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Nutlin-3Axon 1585 CAS [548472-68-0] MF C30H30Cl2N4O4
DescriptionMDM2 antagonist, which binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice. Note: Its two enantiomers, more active (-)-enantiomer Nutlin-3a (Axon 1880) and less active (+)-enantiomer Nutlin-3b (Axon 1881), are also available.
MDM2 inhibitor (p53 specific)
Chemical name4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one Parent CAS No.[548472-68-0] |
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