产品名称

JTP 1048196

产品货号

Axon 2947 CAS [55377-56-5] MF C17H14O4MW 282.29 Purity: 99% Soluble in DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JTP 1048196

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2947

CAS [55377-56-5]

MF C17H14O4
MW 282.29

Purity: 99%
Soluble in DMSO

Recently added

JTP 1048196

Description

JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 (Axon 2939) which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels.

K Katsuya et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System. SLAS Discov. 2018 Dec;23(10):1018-1029.

Cell Signaling & Oncology Pain & Inflammation NF-κB Ubiquitin EC 6.3.2.19 Ubiquitin Ligase (E3; LUBAC)

Prodrug of JTP 0819958; LUBAC inhibitor

Chemical name

3-(2-(2-Methoxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one

Parent CAS No.

[55377-56-5]

产品资料