| 产品名称 | Tenovin 6 - Tnv 6 |
| 产品货号 | Axon 2249 CAS [1011557-82-6] MF C25H34N4O2SMW 454.63 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Small molecule, water soluble p53 activator and SIRT inhibitor (IC50 values of 21 μM, 10 μM, and 67 μM for purified human SIRT1, 2, and 3, respectively, in a peptide deacetylase assay). Tenovin 6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulation of autophagy, without increasing p53-pathway activity. It induces p53-dependent apoptosis in many malignant cells. References Certificates Categories Extra info Lain S. et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008, 13, 454-463. Groves MJ et al. p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia. Br. J. Cancer. 2013, 109, 2434-2444. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics p53 p53-Tumor Suppression DNA-damage Response EC 3.5.1.98 SIRT Small water soluble p53 activator and SIRT inhibitor Chemical name 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide Parent CAS No. [1011557-82-6] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Tenovin 6 - Tnv 6Axon 2249 CAS [1011557-82-6] MF C25H34N4O2S
Description
Small molecule, water soluble p53 activator and SIRT inhibitor (IC50 values of 21 μM, 10 μM, and 67 μM for purified human SIRT1, 2, and 3, respectively, in a peptide deacetylase assay). Tenovin 6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulation of autophagy, without increasing p53-pathway activity. It induces p53-dependent apoptosis in many malignant cells.
Small water soluble p53 activator and SIRT inhibitor
Chemical name4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide Parent CAS No.[1011557-82-6] |
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