产品名称 A 66
产品货号 Axon 1831 CAS [1166227-08-2] MF C17H23N5O2S2MW 393.53 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and specific PI3K p110α inhibitor (IC50: 32 nM); highly selective for p110α over other PI3Ks and having a high degree of specificity as it does not target other protein kinases tested; highly recommended tool in researching p110α isoform References Certificates Categories Extra info S Jamieson et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J. 2011, 438(Pt 1), 53–62.    Ashley J. Waardenberg et al. Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure. J. Biol. Chem. 2011, 286, 30837-30846.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153 PI3K inhibitor (p110-α specific) Chemical name (S)-N1-(2-tert-butyl-4'-methyl-4,5'-bithiazol-2'-yl)pyrrolidine-1,2-dicarboxamide Parent CAS No. [1166227-08-2] Order Size Unit Price Stock 5 mg €95.00 In Stock
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A 66

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1831

CAS [1166227-08-2]

MF C17H23N5O2S2
MW 393.53

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

A 66

Description

Potent and specific PI3K p110α inhibitor (IC50: 32 nM); highly selective for p110α over other PI3Ks and having a high degree of specificity as it does not target other protein kinases tested; highly recommended tool in researching p110α isoform
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