产品名称

VU 6008667

产品货号

Axon 2739 CAS [2092923-21-0] MF C24H17ClF2N2O2MW 438.85 Purity: 99% Optical purity: 98% e.e. Soluble in DMSO and Ethanol Description VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies. KEYWORDS: VU 6008667 | supplier | M5 NAM | VU6008667 | VU-6008667 | CAS [2092923-21-0] | Acetylcholine | CHRM5 | NAM | Receptors | Addiction | Muscarinic

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

VU 6008667

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2739

CAS [2092923-21-0]

MF C24H17ClF2N2O2
MW 438.85

Purity: 99%
Optical purity: 98% e.e.
Soluble in DMSO and Ethanol

VU 6008667

Description

VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies.

KM McGowan et al. Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

CNS CHRM5 A18

Selective NAM of M5 mAChR (CHRM5)

Chemical name

(S)-9b-(4-Chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

Parent CAS No.

[2092923-21-0]

产品资料