| 产品名称 | Rapamycin - Sirolimus |
| 产品货号 | Axon 2069 CAS [53123-88-9] MF C51H79NO13MW 914.17 Purity: 98% Soluble in DMSO Description Specific inhibitor of mTOR (mammalian target of Rapamycin); it binds the cytosolic protein FKBP12 and inhibits mTOR pathway by directly binding the mTORC1. Rapamycin selectively inhibits interleukin-2 (IL-2) activation of p70 S6 kinase. It prevents activation of T cells and B cells by inhibiting their response to IL-2. An immunosuppressant drug used to prevent rejection in organ transplantation, especially useful in kidney transplants; also used as a coronary stent coating References Certificates Categories Extra info CJ Kuo et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992, 358(6381), 70-73. EJ Brown et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994, 369(6483) 756-758. S Kobayashi et al. Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 2007, 98(5), 726-33. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology Immunomodulator mTOR PI3K-Akt-mTOR EC 2.7.11.1 Pfizer Licensed Products Specific inhibitor of mTOR; binds to FKBP12 Chemical name (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [53123-88-9] Order Size Unit Price Stock 2 mg €85.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Rapamycin - SirolimusAxon 2069 CAS [53123-88-9] MF C51H79NO13
Description
Specific inhibitor of mTOR (mammalian target of Rapamycin); it binds the cytosolic protein FKBP12 and inhibits mTOR pathway by directly binding the mTORC1. Rapamycin selectively inhibits interleukin-2 (IL-2) activation of p70 S6 kinase. It prevents activation of T cells and B cells by inhibiting their response to IL-2. An immunosuppressant drug used to prevent rejection in organ transplantation, especially useful in kidney transplants; also used as a coronary stent coating
Specific inhibitor of mTOR; binds to FKBP12
Chemical name(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[53123-88-9] |
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