| 产品名称 | Torin 1 |
| 产品货号 | Axon 1833 CAS [1222998-36-8] MF C35H28F3N5O2MW 607.62 Purity: 98% Poorly soluble in DMSO Description Highly potent, selective and ATP-competitive mTOR inhibitor, with IC50 to be 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases References Certificates Categories Extra info Q Liu et al. Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective mTOR Inhibitor for the Treatment of Cancer. J. Med. Chem. 2010, 53(19), 7146–7155. Q Liu et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available (mTOR) inhibitor for treatment of cancer. J. Med. Chem. 2011, 54(5), 1473-1480. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology mTOR PI3K-Akt-mTOR EC 2.7.11.1 mTOR inhibitor Chemical name 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Parent CAS No. [1222998-36-8] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Torin 1Axon 1833 CAS [1222998-36-8] MF C35H28F3N5O2
Description
Highly potent, selective and ATP-competitive mTOR inhibitor, with IC50 to be 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases
mTOR inhibitor
Chemical name1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Parent CAS No.[1222998-36-8] |
| 产品资料 |
