BEZ 235 - NVP-BEZ235

Based on 1685 publications in PubMed 10 10 1685

Axon 1281

CAS [915019-65-7]

MF C30H23N5O
MW 469.54

Purity: 99%
Moderately soluble in DMSO

BEZ 235

Description

Orally active PI3K tyrosine kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated antiproliferative activity against tumor cell lines in animal models of cancer.

JC Verheijen, A Zask. Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs. Drugs Fut 2007, 32(6), 537.

SM Maira et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008, 7(7), 1851–1863.

R Marone et al. Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors. Mol. Cancer Res. 2009, 7(4), 601-613.

SM Maria, P Furet and F Stauffer. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155.

SM Brachmann et al. Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells. PNAS, 2009, 106 (52), 22299-22304.

List of publications using NVP-BEZ235 (Axon 1281) purchased from Axon Medchem

PI3K and mTOR tyrosine kinase inhibitor

Chemical name

2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile

Parent CAS No.

[915019-65-7]

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