产品名称

SB 332235

产品货号

Axon 2593 CAS [276702-15-9] MF C13H10Cl3N3O4SMW 410.66 Purity: 98% Soluble in 0.1N NaOH(aq) and DMSO Description Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 µM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria. KEYWORDS: SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SB 332235

Based on 62 reference(s) in Google Scholar 9 10 62

Axon 2593

CAS [276702-15-9]

MF C13H10Cl3N3O4S
MW 410.66

Purity: 98%
Soluble in 0.1N NaOH(aq) and DMSO

SB 332235

Description

Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 µM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria.

KEYWORDS: SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis

H Xu et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

PL Podolin et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002 Dec 1;169(11):6435-44.

JR White et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8.

Y Wang et al. Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1. J Neurochem. 2006 Aug;98(4):1046-60.

Apoptosis Cell Signaling & Oncology CNS Immunology Pain & Inflammation A2 Chemokine

Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects

Chemical name

6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide

Parent CAS No.

[276702-15-9]

产品资料