产品名称

LRRK2-IN-1

产品货号

Axon 2493 CAS [1234480-84-2] MF C31H38N8O3MW 570.69 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, ATP-competitive and selective inhibitor of the Parkinson's disease kinase LRRK2 (IC50 value 13 nM and 6 nM for inhibitions of WT and G2019S mutant LRRK2 kinase activity, respectively). LRRK2IN1 is neuroprotective in vitro and inhibits the activity of LRRK2 in kidney and spleen when administered in vivo. However, LRRK 2-IN-1 is not able to cross the BBB. References Certificates Categories Extra info B.K. Gilsbach et al. Structural Characterization of LRRK2 Inhibitors. J Med Chem. 2015 May 14;58(9):3751-6. X. Deng et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol. 2011 Apr;7(4):203-5. L. Munoz et al. Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation. Eur J Med Chem. 2015 May 5;95:29-34. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation LRRK2 Ubiquitin EC 2.7.11.1 Potent, ATP-competitive and selective inhibitor of LRRK2 Chemical name 2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Parent CAS No. [1234480-84-2] Order Size Unit Price Stock 5 mg €85.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LRRK2-IN-1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2493

CAS [1234480-84-2]

MF C31H38N8O3
MW 570.69

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

LRRK2-IN-1

Description

Potent, ATP-competitive and selective inhibitor of the Parkinson's disease kinase LRRK2 (IC50 value 13 nM and 6 nM for inhibitions of WT and G2019S mutant LRRK2 kinase activity, respectively). LRRK2IN1 is neuroprotective in vitro and inhibits the activity of LRRK2 in kidney and spleen when administered in vivo. However, LRRK 2-IN-1 is not able to cross the BBB.