PF 06447475

Based on 44 reference(s) in Google Scholar 10 10 44

Axon 2546

CAS [1527473-33-1]

MF C17H15N5O
MW 305.33

Purity: 99%
Soluble in DMSO

PF 06447475

Description

Highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor (IC50 value 3 nM); an exceptional tool compound to study the function of LRRK2 PF 06447475 mitigates both neurodegeneration and neuroinflammation associated with G2019S-LRRK2 expression by LRRK2 kinase inhibition in rats.

J.L. Henderson et al. Discovery and preclinical profiling of PF-06447475, a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

J.P. Daher et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J Biol Chem. 2015 Aug 7;290(32):19433-44.

Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation LRRK2 Ubiquitin EC 2.7.11.1 Pfizer Licensed Products

Potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor

Chemical name

3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[1527473-33-1]

产品资料