产品名称

PF 04447943 - PF 4447943

产品货号

Axon 2148 CAS [1082744-20-4] MF C20H25N7O2MW 395.46 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity. References Certificates Categories Extra info P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054. M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation EC 3.1.4.35 PDE Selective, brain penetrant PDE9A inhibitor Chemical name 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Parent CAS No. [1082744-20-4] Order Size Unit Price Stock 2 mg €105.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PF 04447943 - PF 4447943

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2148

CAS [1082744-20-4]

MF C20H25N7O2
MW 395.46

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

PF 04447943

Description

Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity.

P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054.

M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068.

Selective, brain penetrant PDE9A inhibitor

Chemical name

6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Parent CAS No.

[1082744-20-4]

产品资料