产品名称

Roblitinib - FGF 401 | NVP-FGF401

产品货号

Axon 2953 CAS [1708971-55-4] MF C25H30N8O4MW 506.56 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Roblitinib - FGF 401 | NVP-FGF401

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2953

CAS [1708971-55-4]

MF C25H30N8O4
MW 506.56

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Recently added

Roblitinib

Description

Roblitinib is a first-in-class, highly selective and potent FGFR4 inhibitor with an IC50 value of 1.1 nM. Roblitinib binds in a reversible covalent manner to the FGFR4 kinase domain. Developed for hepatocellular carcinoma and currently undergoing clinical evaluation for the treatment of FGFR4 and β-klotho positive solid tumors.

D Graus Porta et al. Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC. Proceedings: AACR Annual Meeting 2017; April 1-5, 2017.

T Knoepfel et al. 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4. ACS Med Chem Lett. 2018 Feb 1;9(3):215-220.

HS Schadt et al. Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation. Toxicol Sci. 2018 May 1;163(1):265-278.

First-in-class, highly selective and potent FGFR4 inhibitor

Chemical name

N-(5-Cyano-4-(2-methoxyethylamino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Parent CAS No.

[1708971-55-4]

产品资料