产品名称

Naive Stem Cell 5i inhibitor Set

产品货号

Axon 5011 CAS [N.A.] MF #N/AMW #N/A Purity: 99% Soluble in DMSO Description A convenient set of five small molecule pathway inhibitors (termed as Naive stem cell 5i inhibitors): - BRAF inhibitor SB 590885 (Axon 2504) - MEK inhibitor PD 0325901 (Axon 1408) - ROCK inhibitor Y 27632 dihydrochloride (Axon 1683) - SRC/LCK inhibitor WH 4-023 (Axon 2381) - GSK3β inhibitor IM-12 (Axon 2511).(*Alternatively, CHIR99021 (Axon 1386) can be used as GSK3β inhibitor. Not included.) The combination of five inhibitors of MEK, GSK3β, BRAF, ROCK, and SRC, supports the expansion of viable OCT4-ΔPE-GFP+ human pluripotent cells after exogenous transcription factor expression has been removed. Useful tool for the induction and maintenance of human naive stem cell pluripotency. Read more: Additional Product Information Show all

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现货询价，电话：010-67529703

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axonmedchem

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Naive Stem Cell 5i inhibitor Set

Based on 14 reference(s) in Google Scholar 10 10 14

Axon 5011

CAS [N.A.]

MF #N/A
MW #N/A

Purity: 99%
Soluble in DMSO

Naive Stem Cell 5i inhibitor Set

Description

A convenient set of five small molecule pathway inhibitors (termed as Naive stem cell 5i inhibitors): - BRAF inhibitor SB 590885 (Axon 2504) - MEK inhibitor PD 0325901 (Axon 1408) - ROCK inhibitor Y 27632 dihydrochloride (Axon 1683) - SRC/LCK inhibitor WH 4-023 (Axon 2381) - GSK3β inhibitor IM-12 (Axon 2511).
(*Alternatively, CHIR99021 (Axon 1386) can be used as GSK3β inhibitor. Not included.)
The combination of five inhibitors of MEK, GSK3β, BRAF, ROCK, and SRC, supports the expansion of viable OCT4-ΔPE-GFP+ human pluripotent cells after exogenous transcription factor expression has been removed. Useful tool for the induction and maintenance of human naive stem cell pluripotency.

Show all Axon Ligand™ Sets

KEYWORDS: Naive Stem Cell 5i inhibitor Set | supplier | Stem cell inhibitor set | SB 590885 | PD 0325901 | Y 27632 | WH-4-023 | IM 12 | CAS [405554-55-4] | [391210-10-9] | [129830-38-2] | [837422-57-8] | [1129669-05-1] | Inhibitor | Axon Ligand Sets | BRAF | MEK | ROCK | Src | Lck | GSK3β | naive | expansion | OCT4-ΔPE-GFP+ | pluripotent | hPCs | transcription factor | induction | human | stem cell | hPSC | pluripotency

TW Theunissen et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 2014 Oct 2;15(4):471-87.

List of publications using PD 0325901 (Axon 1408) purchased from Axon Medchem

List of publications using Y 27632 dihydrochloride (Axon 1683) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 SRC ROCK Lck Wnt-β-Catenin PI3K-Akt-mTOR Stem Cells MEK RAF Pfizer Licensed Products

Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency

Chemical name

N.A.

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[N.A.]

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