| 产品名称 | Stem Cell Alternative 2i inhibitor Set |
| 产品货号 | Axon 2130 CAS [N.A.] MF N.A.MW N.A. Purity: 99% Soluble in DMSO Description A convenient set of SRC inhibitor CGP 77675 (Axon 2097) and GSK-3 inhibitor CHIR 99021 (Axon 1386); an alternative 2i inhibitor set vs the conventional 2i inhibitor set (Axon 2128) of MEK inhibitor PD 0325901 and GSK3 inhibitor CHIR 99021. The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos. Read more: Additional Product Information Show all Axon Ligand™ Sets References Certificates Categories Extra info T. Shimizu et al. Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling. Stem Cells 2012, 30, 1394-1404. Certificate of Analysis Material Safety Data Sheet Additional Product Information Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 SRC Wnt-β-Catenin PI3K-Akt-mTOR Stem Cells Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) Chemical name N.A. Parent CAS No. [N.A.] Order Size Unit Price Stock Each 2 mg €110.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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Stem Cell Alternative 2i inhibitor SetAxon 2130 CAS [N.A.] MF N.A.
DescriptionA convenient set of SRC inhibitor CGP 77675 (Axon 2097) and GSK-3 inhibitor CHIR 99021 (Axon 1386); an alternative 2i inhibitor set vs the conventional 2i inhibitor set (Axon 2128) of MEK inhibitor PD 0325901 and GSK3 inhibitor CHIR 99021. The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos. Read more: Additional Product Information Show all Axon Ligand™ Sets
Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386)
Chemical nameN.A. Parent CAS No.[N.A.] |
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