产品名称

RTA 408 | NRF2 acitivator | Omaveloxolone | RTA408 | CAS [1474034-05-3] | Axon 2497 | Axon Ligand™ with >98% purity available from stock from supplier Axon Medchem

产品货号

Axon 2497 CAS [1474034-05-3] MF C33H44F2N2O3MW 554.71 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines and is a highly effective mitigator of steady state hematopoiesis. KEYWORDS: RTA 408 | NRF2 acitivator | Axon 2497 | Omaveloxolone | RTA408 | CAS [1474034-05-3] | DNA-RNA | NRF | Activator | Transcription Factor | NF-E2L2 | ROS | NO | nuclear factor erythroid 2-related factor 2 | JNK | NF-κB | inflammatory | radiation | mitigator | hematopoiesis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

RTA 408 - Omaveloxolone

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2497

CAS [1474034-05-3]

MF C33H44F2N2O3
MW 554.71

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

RTA 408

Description

Synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines and is a highly effective mitigator of steady state hematopoiesis.

S.A. Reisman et al. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiat Res. 2014 May;181(5):512-20.

B.L. Probst et al. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. PLoS One. 2015 Apr 21;10(4):e0122942.

Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB JAK-STAT NRF TF class 1.1.1.2.3

Triterpenoid activator of NRF2 and inhibitor of NF-κB

Chemical name

N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide

Parent CAS No.

[1474034-05-3]

产品资料