PCSK9 Antibody is a Rabbit Polyclonal antibody against PCSK9. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
| Target |
PCSK9 |
| Reactivity |
Human, Mouse |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC, FCM |
| Recommended dilutions |
WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
A synthetic peptide of human PCSK9. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at 2°C to 8°C upon receipt. |
| Molecular Weight |
Calculated MW: 20 kDa/74 kDa
Observed MW: 74 kDa |
| Swiss Prot |
Q8NBP7
|
| GeneID |
255738
|
| Gene Symbol |
PCSK9 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |