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| Product Name | Recombinant Human PDGFRβ Fc Chimera (carrier-free) |
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| Description | PDGF family includes five members, PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC, and PDGF-DD. Two PDGF receptors (a and b) have been described; they belong to the receptor-tyrosine kinase family, Type III group, which also includes c-KIT, FLT3, and M-CSFR. The two PDGF receptor subtypes show different affinities for the dimeric PDGF isoforms. PDGFRa binds to all ligands except PDGF-D, while PDGFRb binds to PDGF-B and -D only. The two PDGF receptors contain five extracellular immunoglobulin-like domains, a single transmembrane domain, and an intracellular split kinase domain, which is formed by two lobes connected by a flexible polypeptide linker, the kinase insert. The binding of PDGFs to their receptors induce receptor dimerization. PDGF receptors are degraded after activation by a mechanism that involves ligand-induced endocytosis and degradation in lysosomes. Soluble form of PDGFRa was detected in conditioned medium of human cell lines. The soluble receptor was derived by proteolytic clipping of the full length PDGFR. Soluble PDGFRb inhibits hepatic stellate cell activation and attenuates liver fibrosis. Also, soluble PDGFRb inhibits intraosseous growth of breast cancer cells in nude mice. PDGFRb mediates recruitment of pericytes and vascular smooth muscle cells to newly formed vessels in response to PDGF-BB secreted by endothelial cells. PDGFRb knockout embryos develop abnormal glomeruli in the kidney (defect development of mesangial cells) capillary microaneurysm, cardiac and placental defects, and die at E16–E19 from hemorrhage. High levels of PDGFRb expression have been associated with tumor recurrence in primary colorectal cancer, and it correlates with poor disease-free survival in pancreatic, colon, and ovarian cancer patients. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Platelet Derived Growth Factor Receptor Beta, Beta Platelet-Derived Growth Factor Receptor, PDGFR-B, PDGFR β, CD140B, CD140b, CD140b Antigen, PDGFR1, PDGF-R-B |
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| Gene, Accession, CAS # | Gene ID: 5159 |
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| Catalog # | 767204 |
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| Order / More Info | Recombinant Human PDGFRβ Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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