| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse IL-15 (carrier-free) |
|---|
| Description | IL-15 was discovered in the supernatant of Simian kidney epithelial cell line CV-1/EBNA, as a soluble factor capable of supporting proliferation of the IL-2-dependent cell line, CTLL-2. IL-15 is a regulatory cytokine, and it is produced by dendritic cells, epithelial cells, fibroblasts, and monocytes. IL-15 plays an important role in immune response and shares many functions with IL-2. For example, it stimulates the proliferation of activated T cells, NK cells, and B cells, and induces immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand. In addition, IL-15 promotes the development of dendritic cells and induces the production of proinflammatory cytokines from macrophages. IL-15 acts as a bridge between innate and adaptive immunity because of its diverse roles in the immune system. IL-15 binds to heterotrimeric receptors composed of IL-15Rα, IL-15Rβ, and IL-15Rγc. IL-15 shares the receptor chains β and γc with IL-2. IL-15 is normally not secreted in soluble form but is instead held on the cell surface bound to a unique receptor, IL-15Rα, especially on dendritic cells. Cell-bound IL-15 is then presented in trans form to T cells and NK cells and is recognized by the γc receptor on these cells; such recognition maintains cell survival and intermittent proliferation. |
|---|
| Size | 10 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Interleukin 15, IL15 |
|---|
| Gene, Accession, CAS # | Gene ID: 16168 |
|---|
| Catalog # | 566302 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse IL-15 (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|