产品名称 PYR41 from CAYMAN CHEMICAL COMPANY
产品货号 15226-25
产品价格 现货询价,电话:010-67529703
产品规格 25 mg
产品品牌 CAYMAN CHEMICAL COMPANY
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Product NamePYR41
DescriptionAn irreversible inhibitor of ubiquitin-activating enzyme (E1; IC50 = 50 = 6.4 µM); selective for E1 over E2 but does inhibit autoubiquitination of the HECT domain E3 Nedd4 at 50 µM; inhibits proteasome-dependent and -independent ubiquitination and protein degradation at 50 µM; preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells at 1-20 µM; also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl
Size25 mg
Concentrationn/a
Applicationsn/a
Other NamesPYR-41 E-1 2 3 auto-ubiquitination NFκB TRAF-6 p-53 JAK-2 Bcrabl Tumor necrosis factor janus kinase 2
Gene, Accession, CAS #CAS: 418805-02-4
Catalog #15226-25
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Order / More InfoPYR41 from CAYMAN CHEMICAL COMPANY
Product Specific Referencesn/a
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