| 产品详情 |
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| Antigenic Specificity | EGF |
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| Clone | M1401E03 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-EGF. Epidermal growth factor (EGF) is a small 6 kD polypeptide and has six conserved cysteine residues that form three intramolecular disulfide bonds. Human EGF is synthesized as transmembrane precursor proteins (1207 amino acids), which are proteolytically cleaved to generate the 54 amino acid mature EGF. EGF/EGF receptor signaling pathway plays an important role in proliferation, differentiation, and migration of a variety of cell types, especially in epithelial cells. The binding of EGF to EGFR induces receptor dimerization, which is required for activating the tyrosine kinase dimerization in the receptor cytoplasmic domain. In addition, the binding of EGF to its receptor triggers several signal transduction pathways including JAK/STAT, Ras/ERK/, and PI3K/AKT pathways. The blocking of the EGF/EGFR pathway can suppress some tumor cell proliferation. |
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| Immunogen | Human EGF, amino acids Asn971 - Arg1023, with an N-terminal Met (Accession# P01133) was expressed in E. coli. |
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| Other Names | Epidermal Growth Factor, Urogastrone (URG), HOMG4 |
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| Gene, Accession # | Gene ID: 1950 |
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| Catalog # | 679502 |
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| Price | |
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| Order / More Info | EGF Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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