产品详情 |
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Antigenic Specificity | LAP (TGF-β1) |
Clone | TW7-16B4 |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1, κ |
Format | Brilliant Violet 421™ conjugate |
Size | 125 µl |
Concentration | n/a |
Applications | Flow Cytometry (FC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Brilliant Violet 421™ anti-mouse LAP (TGF-β1). Transforming growth factor beta (TGF-β) is a cytokine that has critical functions in the immune response by regulating Treg and Th17 cells. TGF-β is first synthesized as pro-TGF-β and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associate peptide (LAP) that non-covalently associates with the dimeric mature TGF-β to prevent its activity. This complex can further associate with latent-TGF-β-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-β can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets. |
Immunogen | Mouse Tgfb1-transduced P3U1 cells |
Other Names | TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-β1, TGF-β |
Gene, Accession # | Gene ID: 21803 |
Catalog # | 141407 |
Price | |
Order / More Info | LAP (TGF-β1) Antibody from BIOLEGEND |
Product Specific References | n/a |
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