| 产品详情 |
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| Antigenic Specificity | LAP (TGF-β1) |
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| Clone | TW7-20B9 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IP, Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-mouse LAP (TGF-β1). Transforming growth factor beta (TGF-β) is a cytokine that has critical functions in immune response by regulating Treg and Th17 cells. TGF-β is first synthesized as pro-TGF-β and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associated peptide (LAP) that non-covalently associates with the dimeric mature TGF-β to prevent its activity. This complex can further associate with latent-TGF-β-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-β can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets. |
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| Immunogen | Mouse Tgfb1-transduced P3U1 cells |
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| Other Names | TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-β1, TGF-β |
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| Gene, Accession # | Gene ID: 21803 |
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| Catalog # | 141302 |
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| Price | |
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| Order / More Info | LAP (TGF-β1) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 22247470 |
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