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| Product Name | Recombinant Human XCL1 (carrier-free) |
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| Description | XCL1, also known as lymphotactin, is an inflammatory chemokine secreted by T cells and natural killer (NK) cells. Early reports described XCL1 as a mediator of T cell and NK cell migrations, but recent studies suggest a highly specialized role for XCL1 and its receptor XCR1. The XCL1-XCR1 axis has been shown to play an important role in dendritic cell mediated cytotoxic immune response and in the formation of self-tolerance mechanisms through the development of regulatory T cells within the thymus. XCL1 also acts as a conformation-dependent inhibitor of HIV-1. Unlike other chemokines, XCL1 conformation interchanges between conserved chemokine folds and an unrelated dimeric structure under physiological conditions. The XCL1 monomer binds XCR1 with a high affinity, whereas the dimer form binds glycosaminoglycan (GAG) with high affinity, but fails to activate XCR1. Human XCL1 encodes a 114 amino acid precursor protein with a 21 amino acid signal peptide and a single disulfide bond. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Lymphotactin, Ltn, ATAC, SCYC1, SCM-1, SCM-1a, lymphotaxin |
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| Gene, Accession, CAS # | Gene ID: 6375 |
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| Catalog # | 758002 |
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| Order / More Info | Recombinant Human XCL1 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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