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| Product Name | PIN1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Source: Recombinant protein corresponding to human PIN1, expressed in E. coli. Molecular Weight: ~18.2kD Biological Activity: >330nmoles/min/mg Endotoxin: <1.0EU/1ug of p |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PIN1, Recombinant, Human (Protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, NIMA-interacting protein 1, DOD, UBL5, Rotamase Pin1, PPIase Pin1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 170037 |
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| Order / More Info | PIN1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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