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| Product Name | Pin1, Recombinant, Mouse, aa1-165, His-Tag (Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1) |
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| Description | Purity ~95% (SDS-PAGE). Pin1, also known as peptidyl-prolyl cis-trans isomerase NIMA-interacting1, is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Source: Recombinant protein corresponding to aa1-165 from mouse PIN1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~20.8kD (188aa), confirmed by MALDI-TOF Endotoxin: 1200nmol/min/mg, and is defined as the |
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| Size | 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_075860 |
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| Catalog # | 377925 |
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| Order / More Info | Pin1, Recombinant, Mouse, aa1-165, His-Tag (Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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