| 产品详情 |
| Edit |   |
|---|
| Product Name | Pin1, Recombinant, Human (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1, PPIase) |
|---|
| Description | Purity ≥95% as determined by SDS-PAGE. Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Recombinant Human PPIase produced in E. coli is a single,non-glycosylated polypeptide chain containing 163 amino acids and having a molecular mass of 18 |
|---|
| Size | 5ug, 20ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | P4190-10 |
|---|
| Price | |
|---|
| Order / More Info | Pin1, Recombinant, Human (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1, PPIase) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|