| 产品详情 |
| Edit |   |
|---|
| Product Name | PLX647 |
|---|
| Description | A dual inhibitor of FMS and KIT (IC50s = 28 and 16 nM, respectively); is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at 1 µM; inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells (IC50s = 380 and 230 nM, respectively); reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release at 40 mg/kg; reduces mast cell degranulation in a mouse model of PCA; inhibits bone destruction and delays disease progression in a mouse model of CIA; reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain |
|---|
| Size | 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 1779796-38-1 PLX 647 FLT-3 MNFS60 M07e HEK-293T Hep-G2 TNFα IL6 interleukin lipopolysaccharide |
|---|
| Gene, Accession, CAS # | CAS: 873786-09-5 |
|---|
| Catalog # | 18012-25 |
|---|
| Price | |
|---|
| Order / More Info | PLX647 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|