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| Product Name | Recombinant Rat C-C motif chemokine protein (Ccl22) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 14.3kDa. Extracellular Domain: 36-161aa. C-terminal 6xHis-tagged. Homo sapiens (Human). Cytotoxic Tlymphocyte 4 (CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4 |
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| Gene, Accession, CAS # | CTLA4, UniProt: P16410 |
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| Catalog # | RPC26969 |
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| Order / More Info | Recombinant Rat C-C motif chemokine protein (Ccl22) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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